MOTS-C 10mg Vial

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16 amino acid peptide encoded inside the mitochondrial genome itself. It was discovered in 2015 by a team at the USC Leonard Davis School of Gerontology and is one of the first identified mitochondria-derived peptides (MDPs): small signalling peptides the mitochondria send out to the rest of the cell and to peripheral tissues when energy status changes. MOTS-C is widely described in the published literature as an 'exercise mimetic' peptide because the AMPK pathway it activates is the same pathway exercise activates.

People use MOTS-C for metabolic health, insulin sensitivity, exercise performance, fat-loss support, and as part of longevity stacks. The published research has reported it activating AMPK (the body's master energy-status sensor), improving glucose uptake into skeletal muscle, increasing exercise capacity in animal models, and reversing some markers of metabolic aging. Levels of natural MOTS-C are reported to decline with age, which is part of the rationale for using it.

MOTS-C is typically injected subcutaneously into the abdomen and is most often cycled rather than run continuously. Common patterns are 5-on-2-off weekly cycles inside a 4–8 week run, then a break. It is a metabolic peptide rather than an aesthetic or recovery peptide, so the effects people report tend to be functional: better workout capacity, better fasted-state energy, easier glucose control, easier fat loss alongside diet and training.

ProPeptide supplies MOTS-C as a lyophilized 10mg vial that you reconstitute with bacteriostatic water using sterile technique. Product specifications and batch documentation are kept product-specific and current. The product is not a licensed medicine and is sold as a research peptide.

Product-specific documentation.

Specifications and documentation are kept product-specific and current.

Sealed lyophilized vial.

Each 10mg vial is lyophilized in a controlled environment and sealed with a crimp cap. You reconstitute with 1mL of bacteriostatic water using sterile technique. That gives a 10mg/mL stock that maps cleanly onto whole insulin units (10 units = 1mg, 20 units = 2mg). The standard for MOTS-C dosing.

Cold-chain, same-day Dubai delivery, UAE-wide.

Orders placed before 4 PM ship the same day inside Dubai. Outside Dubai, order before 12 PM (noon) for next-day delivery to all six other emirates. Orders placed on Saturday will be delivered on Monday, and Sunday delivery is not available outside Dubai. Delivery costs AED 50 below AED 1,000 and is free from AED 1,000. Cold-chain insulated packaging keeps the vial in the +2 to +8°C range from our facility to your door, with ice packs for any leg of the trip that needs them.

Direct from ProPeptide.

Sourced and packed in our own facility. Not relabelled from a middleman. No clinic markups, no distributor margins, no mystery supply chains. We are adding batch-number printing directly to ProPeptide packaging; if you need a box-printed batch number with a matching published COA today, choose the Remedium Research Retatrutide product.

Cycle-friendly format.

MOTS-C is typically cycled rather than run continuously. A 10mg vial supports a full 4–8 week cycle at common doses (5–10mg per cycle), with the option to extend or repeat after a break. The vial is sized so you finish a cycle on roughly one vial, not half-finishing and discarding.

We answer questions, not orders.

We do not give medical advice, but we are happy to walk you through how the product works and what to expect.

MOTS-C is one of the first identified mitochondrial-derived peptides and the most-studied. The published mechanism work spans cell, animal, and early human research. Three pathways come up repeatedly:

AMPK activation (the master energy switch)

MOTS-C is reported to activate AMP-activated protein kinase (AMPK), the cellular sensor that turns on energy-producing pathways when the cell senses low energy. AMPK activation is the same downstream effect that exercise, fasting, and metformin all trigger. It increases glucose uptake into muscle, switches the body toward fat oxidation, and improves insulin sensitivity.

Glucose uptake and insulin sensitivity

Animal-model studies have reported that MOTS-C increases glucose uptake into skeletal muscle independently of insulin, reverses high-fat-diet-induced insulin resistance, and improves glucose tolerance in metabolically stressed animals. This is the basis for using it inside metabolic-health and body-composition protocols.

Exercise mimetic effects

MOTS-C levels rise naturally in response to exercise and metabolic stress. Animal-model studies have reported that MOTS-C administration mimics some of the effects of exercise: improved running capacity, better mitochondrial function, and improved physical performance in older animals. This is why people use it as part of performance and longevity stacks.

Mitochondrial-to-nuclear signalling

MOTS-C is one of the first identified mitochondrial-encoded peptides that travels to the nucleus and changes how nuclear DNA is read. This 'retrograde signalling' is the mechanism by which mitochondria report their health status to the rest of the cell. Levels are reported to decline with age, which is part of the rationale for using it in longevity protocols.

MOTS-C sits in a different category from the GLP-1 family (Retatrutide, Tirzepatide, Semaglutide). It is not an appetite-regulating peptide. It works on the energy and insulin-sensitivity side of the equation. Here is how it compares:

Many people use MOTS-C alongside a GLP-1 protocol. The two target different parts of the metabolic equation and are not in conflict.

MOTS-C is typically cycled rather than run continuously. The most common pattern is a 4–8 week cycle at 5–10mg per cycle, then a break of similar length before repeating. Reconstitute the 10mg vial with 1mL of bacteriostatic water using sterile technique. That gives a 10mg/mL stock where 10 units on a U-100 syringe equals 1mg. The most common per-injection dose.

Dosing ranges above reflect commonly cited community and published protocols. They are reference points, not medical advice. ProPeptide does not provide medical advice. Speak with a qualified healthcare professional before starting any protocol.

To try other water volumes or vial strengths, use the reconstitution calculator.

For dose-to-units math pre-set for this vial, use the MOTS-C dose-to-units calculator.